Updated: October, 2025

Best Ergonomic Mice of 2025

Save up to 21% Off

1

Logitech

9.8

Exceptional

Logitech Lift Vertical Ergonomic Mouse, Wireless, Bluetooth or Logi Bolt USB receiver, Quiet clicks, 4 buttons, compatible with Windows/macOS/iPadOS, Laptop, PC - Graphite

17% Off

Why we love it

Ergonomic design eases wrist strain.

Customizable buttons enhance productivity.

Long battery life for convenience.

Main highlights

Ergonomic Comfort
The Logitech Lift Vertical Ergonomic Mouse offers a natural posture for wrist and forearm comfort.

Versatile Connectivity
Ideal for multiple devices, connect via Bluetooth or USB receiver.

Quiet Clicks
Customers love the whisper-quiet clicks for a distraction-free environment.

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How do we rank?

How do we rank
Our AI-powered platform ranks products using multiple weighted factors from millions of products and user reviews across the web, providing the most valuable and real data. Higher scores rank first.
2

ProtoArc

9.5

Excellent

ProtoArc EM11 NL Ergonomic Mouse, Wireless Vertical Mini Mouse Rechargeable Optical Mice with Multi-Device (2*Bluetooth + USB Connection), 3 Adjustable DPI for Computer, iPad, Mac, Windows Black

21% Off

Why we love it

Reduces wrist and forearm fatigue.

Connects up to three devices.

Quiet clicks for distraction-free work.

Main highlights

Ergonomic Design Comfort
Features ergonomic design with extended wrist rest for reduced fatigue.

Multi-Device Connectivity
Ideal for users needing seamless transition across multiple devices.

Silent Clicking Feature
Praised for quiet operation, perfect for shared environments.

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3

Anker

9.4

Excellent

Anker 2.4G Wireless Vertical Ergonomic Optical Mouse, 800/1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, Macbook - Black

Why we love it

Ergonomic design reduces wrist strain.

Customizable DPI for precise tracking.

Convenient buttons for web browsing.

Main highlights

Ergonomic Design for Comfort
Promotes healthy wrist positions, reducing strain and enhancing comfort.

Ideal for Browsing and Gaming
Perfect for internet surfers and gamers needing efficient navigation.

Praised for Ergonomics
Customers love the ergonomic design for reducing wrist pain.

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4

UGREEN

9.3

Excellent

UGREEN Ergonomic Mouse 2.4G, Vertical Wireless Mouse, 6-Buttons Silent Mice with 4 Adjustable 4000/2000/1600/1000 DPI, USB Receiver and BT5.4 Dual Modes, for Windows/OS/Linux/Android, Laptop/PC, etc.

Main highlights

Ergonomic Design: The ergonomic mouse's 57° vertical grip promotes a natural forearm posture, reducing wrist strain and discomfort for improved comfort and productivity compared to a standard mouse(It does not contain batteries)

Bluetooth 5.4 Connection: The vertical mouse connects in seconds with a reliable pair-and-play Bluetooth 5.4 connection, no dongle or port required

4K DPI Precise Tracking: The UGREEN Bluetooth mouse offers precise tracking on any surface with optical tracking technology, including glass, with 4 adjustable DPI levels (4000/2000/1600/1000), making it ideal for detailed tasks like CAD drafting

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5

TECKNET

9.0

Excellent

TECKNET Ergonomic Mouse, 4800DPI Wireless Vertical Mouse 6-Button Silent Mice with 5 Adjustable Levels DPI, USB Receiver, 2.4G Cordless Computer Mouse Optical Wireless Mouse for Laptop, PC, Mac

15% Off

Why we love it

Ergonomic design reduces wrist fatigue.

Quiet clicks for a noise-free environment.

Adjustable DPI for precise control.

Main highlights

Ergonomic Design Benefits
Vertical design with a 57° tilt reduces hand fatigue.

Ideal for Gamers and Designers
4800 DPI provides fast cursor movement and accuracy.

Praised Silent Operation
Reduces clicking noise by 95%, ideal for quiet spaces.

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6

TECKNET

8.9

Very Good

TECKNET Wired Ergonomic Mouse, 6400DPI Wired Vertical Mouse 6-Button Silent Mouse with 4 Adjustable Levels DPI, 1.5 m USB Cable Optical WiredMouse for Laptop, PC, Mac,Black

10% Off

Why we love it

Adjustable DPI for versatile use.

Ergonomic design reduces hand strain.

Silent clicks for noise-free operation.

Main highlights

Adjustable DPI Levels
The mouse offers 4 DPI settings (6400/3200/1600/1000) for precision.

Ideal for Ergonomic Comfort
Perfect for gamers, designers, and office workers needing comfort.

Praised Silent Click Feature
Users appreciate the quiet operation, reducing noise by 95%.

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7

acer

8.8

Very Good

acer Wireless Mouse, 3 Adjustable DPI Ergonomic Computer Mouse 2.4GHz with USB Receiver, 6 Buttons, Cordless Optical Tracking, Battery Indicator, Portable Mice Wireless for Laptop, PC, Desktop, Mac

Main highlights

【Stable Connection, Plug and Play】Acer computer mouse adopts 2.4GHz wireless connection, which can provide stable and interference-free connection within 8 meters. Just plug in the USB-A receiver and it can be used immediately without driver. The mouse receiver is behind the battery compartment with "Receiver Inside" printed on it, which is easy to carry.

【Compact Mouse】Acer wireless mouse is ergonomically designed for the right hand, moulded to fit the hand shape with excellent hand feeling, far better than a trackpad, suitable for long-term office or entertainment.

【3 DPI Adjustable】This pc mouse supports 800/1200/1600 DPI 3-speed switching, providing different mouse speeds, and easily adapting to various usage needs such as office, browsing, daily small games, etc.

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8

TECKNET

8.7

Very Good

TECKNET Ergonomic Mouse, Bluetooth Rechargeable Vertical Mouse (BT5.0/3.0+USB-A), Wireless Right handed Mouse 6-Button, Optical Mouse 4800 DPI 6 Adjustable Levels,Quiet Clicks,Wide Compatibility-Black

16% Off

Main highlights

【Right Handed Ergonomic Design】The Right handed wireless mouse features a vertical ergonomic design with a 52° tilt angle. It positions your palm near-vertically, unlike traditional mice; it keeps your wrist joint natural and relaxed, minimizing fatigue and discomfort from prolonged use. This design offers ultimate comfort, a more enjoyable and longer-lasting office experience. (Note: Mouse is designed for right-handed use only).

【Rechargeable Wireless Mouse】The wireless ergonomic mouse has a built-in 600mAh lithium battery that can be easily recharged by the supplied Type-C cable. It lasts for 60 days of use and 90 days standby on a full charge. Additionally, the ergonomic mice enter power-saving mode (completely cutting off power) after being idle for about 8 minutes; you can wake it by pressing the right or left button. The ON/OFF switch and intelligent sleep mode also help to save energy. No need to charge the Rechargeable mouse frequently.

【Fast Switching Between Three Devices】The Bluetooth mice feature Bluetooth 5.0, 3.0 and USB-A receiver modes for connectivity. When connected via Bluetooth (Bluetooth mode supports simultaneous connections to two devices), the vertical mice effectively reduce need for a USB-A port, making it ideal for devices without USB ports. Simply press the button on the back to easily switch between the two modes.(Note: The 2.4GHz receiver is built into the bottom of the mouse).

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9

Anker

8.5

Good

Anker® Ergonomic Optical USB Wired Vertical Mouse 1000/1600 DPI, 5 Buttons

20% Off

Why we love it

Ergonomic design reduces wrist strain.

Smooth tracking with optical technology.

Convenient browsing with extra buttons.

Main highlights

Ergonomic Design
Encourages neutral wrist position for reduced strain and smoother movement.

Ideal for Long Use
Perfect for internet surfers, gamers, and prolonged computer work.

Praised Feature: Comfort
Customers love the comfort provided by the ergonomic design.

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10

TechRise

8.2

Good

TechRise Ergonomic Mouse, 4800 DPI Wireless Vertical Mouse, 2.4G Optical Computer Mouse with 5 Adjustable DPI, Silent Mouse with 6 Ergo Buttons for PC/Laptop/Mac, Black

Why we love it

Ergonomic design reduces wrist strain.

Adjustable DPI for precise control.

Silent clicks for a quiet environment.

Main highlights

Ergonomic Design for Comfort
Aligns wrist at a 57° angle for natural posture.

Ideal for Quiet Environments
Perfect for offices, libraries, and home use.

Praised Silent Clicking
Up to 95% noise reduction for soft-click buttons.

More info

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Our top 3 picks

1
17% Off

Logitech Lift Vertical Ergonomic Mouse, Wireless, Bluetooth or Logi Bolt USB receiver, Quiet clicks, 4 buttons, compatible with Windows/macOS/iPadOS, Laptop, PC - Graphite
The Logitech Lift Vertical Ergonomic Mouse is designed for small to medium right hands, offering unparalleled comfort and productivity. Its vertical shape encourages a natural wrist position, reducing strain during extended use. With its cordless design, customizable buttons, and whisper-quiet clicks, this mouse is perfect for professionals seeking focus and efficiency. Connectivity is versatile, supporting Bluetooth or Logi Bolt USB across various operating systems, including Windows, macOS, iPadOS, and more. Enjoy up to two years of battery life, making it a reliable companion for long-term use. Additionally, the mouse is crafted with recycled materials and is carbon neutral, aligning with eco-conscious values. Whether you're working on a desktop or a laptop, the Logitech Lift ensures a seamless and comfortable experience.
2
21% Off

ProtoArc EM11 NL Ergonomic Mouse, Wireless Vertical Mini Mouse Rechargeable Optical Mice with Multi-Device (2*Bluetooth + USB Connection), 3 Adjustable DPI for Computer, iPad, Mac, Windows Black
The ProtoArc EM11 NL Ergonomic Mouse is designed for comfort and efficiency, featuring an ergonomic shape with an extended wrist rest to reduce forearm and wrist fatigue. This wireless vertical mouse connects to up to three devices simultaneously via dual Bluetooth 4.0 and 2.4G USB modes, making it ideal for multitaskers who switch between devices frequently. Its built-in rechargeable battery ensures convenience, while the whisper-quiet clicking is perfect for shared workspaces like offices and libraries. With adjustable DPI levels (1000/1600/2400), it offers precise tracking and improved work efficiency. However, it's important to note that the forward and back buttons are not compatible with Mac OS systems. Overall, this mouse is a great choice for anyone seeking a comfortable, versatile, and quiet mouse for both professional and personal use.
3

Anker 2.4G Wireless Vertical Ergonomic Optical Mouse, 800/1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, Macbook - Black
The Anker AK-UBA 2.4G Wireless Vertical Ergonomic Optical Mouse is designed with user comfort in mind, featuring an ergonomic design that encourages a natural handshake position to minimize wrist strain. Its optical tracking technology offers adjustable DPI settings (800/1200/1600), providing smooth and precise tracking across various surfaces, making it ideal for both casual browsing and gaming. The mouse includes convenient next/previous buttons, enhancing the browsing experience for internet users and professionals alike. Additionally, its power-saving mode ensures energy efficiency by cutting off power after 8 minutes of inactivity, easily reactivating with a click. The product comes with an 18-month hassle-free warranty, ensuring reliability and peace of mind. Overall, this mouse combines comfort, precision, and convenience, making it a top choice for users seeking an ergonomic and efficient computing experience.